• Sam_Bass@lemmy.world
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    5 days ago

    they tried that a few years back via a quadraplegics brain transplant to a normal body. he died on the table. not likely to change that with cloning

      • Sam_Bass@lemmy.world
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        5 days ago

        go look at images of old telephone wiring like when POTS was still the main method.multiply those rats nests of wires by a billion and shrink that them down to the molecular size and you might see the issue

        • Excrubulent@slrpnk.net
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          4 days ago

          I cut a big nerve in my thumb years ago, and apparently plastic surgeons fix that sort of thing.

          They reattached the nerve bundles, but I was told the sheathes could be realigned, but the nerves would have to grow back from the point of the cut all the way to the skin.

          At first one half of my thumb was entirely numb, and over the course of well over a decade I’d get pins & needles as bunches of nerves would finish regrowing, except attached to random channels in the nerve bundle, so my brain had to completely remap all those signals to what they actually meant. Also extreme nerve pain near the cut whenever it was bumped, I assume because many nerves just didn’t grow successfully and remained near that site.

          It felt super weird because hot, cold, pain & touch were all mixed up, but eventually my brain sorted them out. It still feels a little weird, especially near my nail, but I haven’t had a pins & needles experience for a few years.

          The problem with doing that with a neck is that it would take wayyy longer and the chances of the patient dying from complications due to no brain signals working right… yeah I don’t see medical science fixing this unless we can regrow nerves in a much shorter span of time.

          • threelonmusketeers@sh.itjust.works
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            15 hours ago

            At first one half of my thumb was entirely numb, and over the course of well over a decade I’d get pins & needles as bunches of nerves would finish regrowing, except attached to random channels in the nerve bundle, so my brain had to completely remap all those signals to what they actually meant.

            It felt super weird because hot, cold, pain & touch were all mixed up, but eventually my brain sorted them out.

            Wow, that’s fascinating. Thanks for sharing your story.

            • Excrubulent@slrpnk.net
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              15 hours ago

              Thanks! As far as I know I’m not describing anything too unusual with the mixed-up signals, I think pins & needles is essentially that, just a bunch of nerves randomly firing, so you probably do know what it’s like in little doses.

              I’ve been paying attention to it since I wrote that, and it definitely is still slightly more numb on the affected side, I think I was right that not all the nerves regrew completely.

  • jpreston2005@lemmy.world
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    6 days ago

    There are two reasons he believes the neocortex could be replaced, albeit only slowly. The first is evidence from rare cases of benign brain tumors, like a man described in the medical literature who developed a growth the size of an orange. Yet because it grew very slowly, the man’s brain was able to adjust, shifting memories elsewhere, and his behavior and speech never seemed to change—even when the tumor was removed.

    That’s proof, Hébert thinks, that replacing the neocortex little by little could be achieved “without losing the information encoded in it” such as a person’s self-identity.

    The second source of hope, he says, is experiments showing that fetal-stage cells can survive, and even function, when transplanted into the brains of adults. For instance, medical tests underway are showing that young neurons can integrate into the brains of people who have epilepsy and stop their seizures.

    “It was these two things together—the plastic nature of brains and the ability to add new tissue—that, to me, were like, ‘Ah, now there has got to be a way,’” says Hébert.

    Very interesting. I’ve also seen research suggesting that the application of stem cells to damaged neural tissue within the spinal cord could repair it, so the idea that you could use a similar approach to actual brain health isn’t such a big leap. But still, wow. I wonder how long it would take for the immature cells to develop into “adult mode” that’s fully integrated into the patients cortex. In order to replace the entire brain, you’d have to do it in like, 8 parts, with years of recovery time in between each surgery. Also there would exist the potential for the new cells to develop into like, a second, smaller brain, if the connections sour or if the new material isn’t stimulated the “right” way.

    • threelonmusketeers@sh.itjust.works
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      15 hours ago

      a man described in the medical literature who developed a growth the size of an orange. Yet because it grew very slowly, the man’s brain was able to adjust, shifting memories elsewhere, and his behavior and speech never seemed to change—even when the tumor was removed.

      Wow, that’s wild.